摘   要：目的  分析甲巰咪唑與糖皮質激素聯合治療甲狀腺功能亢進癥合并癥的臨床效果。方法  收集我院2016年3月～2017年3月收治的130例甲狀腺功能亢進癥合并癥患者作為研究對象，隨機分為A組和B組，每組65例，A組采用甲巰咪唑治療，B組采用甲巰咪唑與糖皮質激素聯合治療。對比兩組患者臨床療效以及肝功能情況。結果  B組患者治療總有效率53.85%高于A組患者的35.38%， 差異有統計學意義（P<0.05）。治療后兩組患者丙氨酸氮基轉氨酶和天門冬氨酸基轉氨低于治療前，差異有統計學意義（P<0.05）。B組患者治療后丙氨酸氮基轉氨酶和天門冬氨酸基轉氨低于A組，差異有統計學意義（P<0.05）。結論  甲巰咪唑與糖皮質激素聯合治療甲狀腺功能亢進癥合并癥效果良好，能促進患者肝功能改善，加速患者恢復，因此可進行臨床推廣應用。
　　關鍵詞：甲狀腺功能亢進癥合并癥;甲巰咪唑;糖皮質激素
　　中圖分類號：R581.1                                  文獻標識碼：A                                DOI：10.3969/j.issn.1006-1959.2018.05.048
　　文章編號：1006-1959（2018）05-0136-02
　　Analysis of Effects of Methimazole and Glucocorticoids on Complications of Hyperthyroidism
　　MIAO Yan-ru
　�。―epartment of Endocrinology，Suizhong County Hospital，Suizhong 125200，Liaoning，China）
　　Abstract：Objective  To analyze the clinical effect of methimazole and glucocorticoids in the treatment of hyperthyroidism complications.Methods  A total of 130 cases of hyperthyroidism comorbidities treated in our hospital from March 2016 to March 2017 were collected and randomly divided into group A and group B，with 65 cases in each group.Group A was treated with methimazole. Group B was treated with methimazole and glucocorticoids.The clinical efficacy and liver function of the two groups were compared. Results  The total effective rate of treatment in group B was 53.85%，which was higher than that in group A 35.38%，the difference was statistically significant（P<0.05）.After treatment，alanine aminotransferase and aspartate aminotransferase were lower than before treatment in the two groups，the difference was statistically significant（P<0.05）.Group B of patients after treatment of alanine aminotransferase and aspartate amino transaminase is lower than the group A，the difference was statistically significant（P<0.05）. Conclusion  Methimazole combined with glucocorticoids in the treatment of hyperthyroidism complications with good effect，can promote liver function improvement，accelerate the recovery of patients，it can be carried out in clinical application.
　　Key words：Hyperthyroidism complication;Methimazole;Glucocorticoid
　　甲狀腺功能亢進癥合并癥（hyperthyroidism complication）是一種比較常見的內分泌系統疾病，這種疾病能夠對患者的消化系統以及造血系統造成比較大的傷害，目前臨床治療主要采用甲巰咪唑和丙巰氧嘧啶，或聯合倍他樂克等β受體阻滯劑治療。有研究表明[1]，單純應用抗甲狀腺藥物治愈率只有50%，且會造成患者白細泡降低，肝功能受損等不良反應發(fā)生，基于此，現對綏中縣醫(yī)院內分泌科2016年3月～2017年3月收治的130例甲狀腺功能亢進癥合并癥患者，進行甲巰咪唑與糖皮質激素聯合治療對臨床效果及肝功能損害，現總結如下。

相關熱詞搜索：咪唑 合并癥 激素 效果 治療