[摘要]目的 評(píng)價(jià)米索前列醇不同的給藥途徑治療稽留流產(chǎn)的臨床效果。方法 選取莆田學(xué)院附屬醫(yī)院2015年1月～2016年6月收治的80例稽留流產(chǎn)患者作為研究對(duì)象，隨機(jī)分為試驗(yàn)組和對(duì)照組，每組各40例。試驗(yàn)組給予米非司酮150 mg口服聯(lián)合米索前列醇片0.6 mg塞陰，對(duì)照組給予米非司酮150 mg口服聯(lián)合米索前列醇片0.6 mg口服。觀察比較兩組患者的子宮收縮時(shí)間、服藥后排胚時(shí)間、排胚后2 h出血量及完全流產(chǎn)率。結(jié)果 試驗(yàn)組患者的子宮收縮時(shí)間及排胚時(shí)間明顯早于對(duì)照組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；試驗(yàn)組排胚后2 h出血量明顯少于對(duì)照組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。試驗(yàn)組完全流產(chǎn)率為20.0%，高于對(duì)照組的5.0%，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 米非司酮聯(lián)合米索前列醇塞陰治療稽留流產(chǎn)的臨床效果明顯優(yōu)于米非司酮聯(lián)合米索前列醇口服，排胚后清宮率較低。
　　[關(guān)健詞]米非司酮；米索前列醇；給藥途徑；臨床療效
　　[中圖分類號(hào)] R378.5 [文獻(xiàn)標(biāo)識(shí)碼] A [文章編號(hào)] 1674-4721（2018）2（b）-0053-03
　　Analysis on the clinical effect of different routes of medication in the treatment of missed abortion
　　HUANG Jian-xiong LI Li-jun CHI Hui-juan
　　Department of Obstetrics and Gynecology，Affiliated Hospital of Putian College，F(xiàn)ujian Province，Putian 351100，China
　　[Abstract]Objective Evaluation of clinical effect of Misoprostol on different routes of medication in the treatment of missed abortion.Methods 80 cases of patients with missed abortion from putian college affiliated hospital from January 2015 to June 2016 were selected as the subjects，and randomly divided into the experimental group and the control group，40 cases in each group.The test group received 150 mg oral Mifepristone combined with Misoprostol 0.6 mg plug vagina.The control group received 150 mg oral Mifepristone combined with Misoprostol 0.6 mg oral.The uterine contraction time，time of discharge of embryo after taking medicine，the amount of bleeding and the rate of complete abortion after 2 hours between the two groups were observed and compared.Results In the experimental group，the time of uterine contraction and the discharge time were significantly less than those in the control group，the difference was statistically significant （P<0.05）.The amount of bleeding in the experimental group was significiantly less than that in the control group after 2 h，the difference was statistically significant （P<0.05）.The complete abortion rate was 20.0% in the test group，higher than 5.0% in the control group，the difference was statistically significant （P<0.05）.Conclusion Mifepristone combined Misoprostol plug vagina for missed abortion has better clinical efficacy than Mifepristone combined Misoprostol oral，which has the lower rate of embryos after discharge.
　　[Key words]Mifepristone；Misoprostol；Routes of medication；Clinical effect
　　稽留流產(chǎn)，是自然流產(chǎn)的一種特殊類型，指胚胎或胎兒已死亡滯留宮腔內(nèi)未能及時(shí)自然排出。研究發(fā)現(xiàn)，稽留流產(chǎn)的發(fā)病率逐年上升，占所有自然流產(chǎn)的42.21%，而發(fā)生在妊娠8周以前占80%[1]。處理稽留流產(chǎn)的方法有藥物治療和刮宮治療。由于大部分患者有生育要求且擔(dān)心刮宮術(shù)的副作用，所以更適合藥物治療。米非司酮聯(lián)合米索前列醇應(yīng)用于稽留流產(chǎn)的藥物治療效果確切，但由于其排胚后出血時(shí)間長(zhǎng)及排胚后完全流產(chǎn)率低等不足，限制了其應(yīng)用范圍。本研究旨在探討米索前列醇的不同給藥方式聯(lián)合米非司酮治療稽留流產(chǎn)的臨床效果，現(xiàn)報(bào)道如下。

相關(guān)熱詞搜索：稽留 流產(chǎn) 臨床 給藥 途徑