探討序貫神經阻滯治療惡性腫瘤放化療并發(fā)帶狀皰疹的臨床療效
發(fā)布時間:2018-06-23 來源: 日記大全 點擊:
【摘要】 目的 探討序貫神經阻滯治療惡性腫瘤放化療并發(fā)帶狀皰疹的臨床療效。方法 46例惡性腫瘤放化療并發(fā)帶狀皰疹患者, 隨機分為觀察組和對照組, 各23例。對照組采用常規(guī)治療方法, 觀察組在對照組基礎上采用序貫神經阻滯治療, 比較兩組患者止皰、結痂、脫痂、疼痛緩解時間及治愈情況和遺留神經痛情況。結果 觀察組止皰、結痂、脫痂、疼痛緩解時間均短于對照組, 差異有統(tǒng)計學意義(P<0.05)。觀察組治愈率86.67%明顯高于對照組的63.33%, 遺留神經痛發(fā)生率6.67%明顯低于對照組的33.33%, 差異有統(tǒng)計學意義(P<0.05)。結論 采用序貫神經阻滯治療惡性腫瘤放化療并發(fā)帶狀皰疹能夠達到較好的臨床效果, 臨床應早發(fā)現、早治療, 以提升治愈率, 提高患者生存質量。
【關鍵詞】 惡性腫瘤;放化療;帶狀皰疹;早期治療;臨床觀察
DOI:10.14163/j.cnki.11-5547/r.2018.12.048
【Abstract】 Objective To discuss the clinical efficacy of sequential nerve block in the treatment of malignant tumor with radiotherapy and chemotherapy complicated with herpes zoster. Methods A total of
46 patients with malignant tumor with radiotherapy and chemotherapy complicated with herpes zoster were randomly divided into observation group and control group, with 23 cases in each group. The control group received conventional therapy, and the observation group received sequential nerve block on the basis of the control group. Comparison were made on herpes stopping, scarring and dislocation time, pain relief time, healing and residual neuralgia between the two groups. Results The observation group had shorter herpes stopping, scarring and dislocation time, pain relief time than the control group, and the difference was statistically significant (P<0.05). The observation group had obviously higher healing rate as 86.67% than 63.33% in the control group, and obviously lower prevalence of residual neuralgia as 6.67% than 33.33% in the control group. Their difference was statistically significant (P<0.05). Conclusion Sequential nerve block for the treatment of malignant tumor with radiotherapy and chemotherapy complicated with herpes zoster can achieve better clinical effect. Early detection and early treatment can improve the healing rate and improve the quality of life of patients.
【Key words】 Malignant tumor; Radiotherapy and chemotherapy; Early treatment; Clinical observation
帶狀皰疹是臨床常見的免疫抑制類疾病, 惡性腫瘤患者均存在不同程度的細胞免疫缺陷, 加之放化療治療對免疫系統(tǒng)的破壞, 導致帶狀皰疹的發(fā)病率明顯高于普通人群。惡性腫瘤放化療并發(fā)帶狀皰疹病情嚴重, 皰疹分布廣, 病情進展迅速, 易導致全身衰竭, 預后極差。臨床的早期干預治療是改善預后的關鍵, 但常規(guī)抗病毒治療后容易遺留神經痛, 給患者帶來極大的身心痛苦[1]。本研究分析惡性腫瘤放化療并發(fā)帶狀皰疹的臨床治療, 旨在提升療效, 減輕患者痛苦, 現具體報告如下。
1 資料與方法
1. 1 一般資料 選取2009年6月~2016年6月在本院腫瘤科治療的46例惡性腫瘤放化療并發(fā)帶狀皰疹患者, 隨機分為觀察組和對照組, 各23例。觀察組中男12例, 女11例, 年齡47~76歲, 平均年齡(64.3±10.4)歲。對照組中男13例, 女10例, 年齡45~78歲, 平均年齡(65.2±10.9)歲。兩組患者的性別、年齡等一般資料比較差異無統(tǒng)計學意義(P>0.05), 具有可比性。所有患者均符合惡性腫瘤放化療并發(fā)帶狀皰疹診斷標準, 均采用姑息性放療或化療治療, 在治療期間或治療后有神經痛前驅癥狀, 簇集性水泡沿神經分布, 以胸腰部為主;皰疹多為粟粒至綠豆大小, 簇集成群沿周圍神經成帶狀分布, 皰疹中心有臍凹, 周圍明顯紅暈, 部分水皰破潰、糜爛及結痂;排除有藥物禁忌證、嚴重肝腎功能障礙者。
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