【摘要】 目的 探討阿司匹林抵抗（AR）與冠心病合并2型糖尿病患者不良心血管事件（MACE）發(fā)生的關(guān)系。方法 120例冠心病合并2型糖尿病患者， 根據(jù)是否發(fā)生AR分為AR組與非AR組， 比較兩組的MACE發(fā)生情況， 并根據(jù)患者是否發(fā)生MACE分為發(fā)生組與未發(fā)生組， 比較患者的一般資料， 進(jìn)而分析AR等與冠心病合并2型糖尿病患者發(fā)生MACE的關(guān)系。結(jié)果 AR組MACE發(fā)生率51.43%明顯高于非AR組的23.53%， 差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。發(fā)生組性別、收縮壓、舒張壓、總膽固醇（TC）、高密度脂蛋白膽固醇（HDL-C）、空腹血糖（FBG）水平與未發(fā)生組比較差異無(wú)統(tǒng)計(jì)學(xué)意義（P>0.05）;發(fā)生組年齡、體質(zhì)量指數(shù)（BMI）、三酰甘油（TG）、低密度脂蛋白膽固醇（LDL-C）、糖化血紅蛋白（HbA1c）、AR發(fā)生情況與未發(fā)生組比較差異具有統(tǒng)計(jì)學(xué)意義（P<0.05）。經(jīng)Logistic分析分析， 年齡、LDL-C、HbA1c、AR是影響MACE發(fā)生的因素（P<0.05）。結(jié)論 存在AR的冠心病合并糖尿病患者發(fā)生MACE的風(fēng)險(xiǎn)更高， 年齡、LDL-C、HbA1c、AR均是導(dǎo)致MACE發(fā)生的危險(xiǎn)因素。
　　【關(guān)鍵詞】 阿司匹林抵抗;2型糖尿病;不良心血管事件;冠心病
　　DOI：10.14163/j.cnki.11-5547/r.2018.12.002
　　【Abstract】 Objective To investigate the relationship between aspirin resistance （AR） and main adverse cardiovascular events （MACE） in patients with type 2 diabetes mellitus complicated with coronary heart disease. Methods A total of 120 patients with type 2 diabetes mellitus complicated with coronary heart disease were divided by occurrence of AR into AR group and non-AR group. The occurrence of MACE in the two groups was compared， and the patients were divided by occurrence of MACE into the occurrence group and non-occurrence group. The general data of patients was compared， and then the relationship between AR and MACE in patients with coronary heart disease and type 2 diabetes mellitus was analyzed. Results AR group had obviously higher incidence of MACE as 51.43% than 23.53% in non-AR group， and the difference was statistically significant （P<0.05）. The occurrence group had no statistically significant difference in gender， systolic blood pressure， diastolic blood pressure， total cholesterol （TC）， high density lipoprotein cholesterol （HDL-C）， and fasting blood glucose （FBG） level， comparing with non-occurrence group （P>0.05）. The occurrence group had statistically significant difference in age， body mass index （BMI）， triglyceride （TG）， low density lipoprotein cholesterol （LDL-C）， glycosylated hemoglobin （HbA1c） and AR occurrence， comparing with non-occurrence group （P<0.05）. According to Logistic analysis， age， LDL-C， HbA1c and AR were factors affecting the occurrence of MACE （P<0.05）. Conclusion There is a higher risk of MACE in patients with coronary heart disease and diabetes mellitus who have AR. Age， LDL-C， HbA1c and AR are all risk factors for the occurrence of MACE.
　　【Key words】 Aspirin resistance; Type 2 diabetes mellitus; Main adverse cardiovascular events; Coronary heart disease
　　多數(shù)冠心病患者合并有2型糖尿病， 二者�；�為因果， 加重患者的病情， 增加MACE的發(fā)生風(fēng)險(xiǎn)[1， 2]�？寡�小板治療是預(yù)防心血管疾病和血栓事件發(fā)生的重要手段， 受到個(gè)體差異影響， 不同個(gè)體對(duì)抗血小板藥物治療的反應(yīng)存在差異， 在接受抗血小板藥物治療仍會(huì)發(fā)生血栓事件， 即“血小板抵

相關(guān)熱詞搜索：阿司匹林 冠心病 糖尿病患者 抵抗 合并