[摘要] 目的 探討不同孕期攝食抑制因子（Nesfatin-1）、C-反應(yīng)蛋白（CRP）及血清鐵蛋白（SF）水平及其與妊娠期糖尿�。℅DM）的關(guān)系。 方法 選取2015年6月～2017年1月在河北省唐山市婦幼保健院建檔并行孕早期（11～13周）檢查的103例孕婦作為研究對象，根據(jù)孕中期葡萄糖耐量試驗(yàn)糖代謝正常是否分為試驗(yàn)組（47例）和對照組（56例）。對兩組患者孕中期一般情況（包括年齡、孕齡、體重指數(shù)、空腹血糖、空腹胰島素）、孕早期和孕中期血清Nesfatin-1、CRP及SF水平進(jìn)行比較，采用Logistic回歸對GDM的相關(guān)因素進(jìn)行分析。 結(jié)果 兩組孕中期年齡、孕齡、體重指數(shù)比較，差異無統(tǒng)計(jì)學(xué)意義（P > 0.05），試驗(yàn)組空腹血糖及空腹胰島素水平均高于對照組，差異有統(tǒng)計(jì)學(xué)意義（P < 0.05）。試驗(yàn)組孕早期及孕中期血清Nesfatin-1、CRP、SF水平均高于對照組，差異均有統(tǒng)計(jì)學(xué)意義（P < 0.05）。試驗(yàn)組孕中期血清上述指標(biāo)水平均高于孕早期，差異有統(tǒng)計(jì)學(xué)意義（P < 0.05）；對照組孕中期上述指標(biāo)水平與孕早期比較，差異無統(tǒng)計(jì)學(xué)意義（P > 0.05）。Logistic多因素回歸分析顯示，空腹血糖、空腹胰島素及血清Nesfatin-1、CRP及SF是GDM發(fā)生的危險(xiǎn)因素（P < 0.05）。 結(jié)論 血清Nesfatin-1、CRP及SF異常表達(dá)是GDM發(fā)生的危險(xiǎn)因素，且在孕早期GDM患者血清Nesfatin-1、CRP及SF較正常孕婦已有升高，通過其水平檢測有利于早期發(fā)現(xiàn)GDM，使患者血糖得到有效控制，對改善妊娠結(jié)局具有重要意義。
　　[關(guān)鍵詞] 妊娠期糖尿病；Nesfatin-1；C-反應(yīng)蛋白；血清鐵蛋白
　　[中圖分類號(hào)] R711.75 [文獻(xiàn)標(biāo)識(shí)碼] A [文章編號(hào)] 1673-7210（2018）02（c）-0098-05
　　Difference on the levels of Nesfatin-1， C-reactive protein and serum ferritin in different gestational periods in patiens with gestational diabetes mellitus and their relationship
　　JIANG Haiying ZUO Jinling SANG Xuemei WANG Qian ZHAO Jing
　　Department of Gynaceology and Obstetrics， Maternal and Child Health Hospital of Tangshan， Heibei Province， TangShan 063000， China
　　[Abstract] Objective To investigate the levels of Nesfatin-1， C-reactive protein （CRP） and serum ferritin （SF） of different gestational periods in patients with gestational diabetes mellitus （GDM） and their relationship. Methods From June 2015 to January 2017， 103 patients in early pregnancy built profile and examined in Maternal and Child Health Hospital of Tangshan were selected as research objects and divided into the test group （47 cases） and the control group （56 cases） by the oral glucose tolerance test. The general conditions （includes age， gestational weeks， BMI， fasting blood glucose and fasting insulin） in middle pregnancy between the two groups were compared and the levels of Nesfatin-1， CRP and SF in the early and middle pregnancy between the two groups were compared. The logistic regression analysis was used to analyze the related factors of GDM. Results There were no statistically significant differences in the age， gestational weeks and BMI between the two groups in the middle pregnancy （P > 0.05）. The fasting blood glucose and fasting insulin in the test group were higher than those of control group， with statistically significant differences（P < 0.05）. In the early and middle pregnancy， the levels of Nesfatin-1， CRP and SF in the test group were higher than those of control group， with statistically significant differences （P < 0.05）. In the test group， the indicators above in the middle pregnany were higher than those of early pregnany， with statistically significant differences （P < 0.05）； in the control group， there were no statistically significant differences in the above indicators between the early and middle pregnany （P < 0.05）. The Logistic regressive analysis showed that the fasting blood glucose， fasting insulin， Nesfatin-1，CRP and SF were the risk factors of GDM （P < 0.05）. Conclusion Serum Nesfatin-1， CRP and SF are the risk factors of GDM. In early pregnancy of GDM patients， Nesfatin-1， CRP and SF are higher than those in normal pregnant women and it is helpful for early detection of GDM， so as to control the patients′ blood glucose effectively， which is of great significance to improve the pregnancy outcome.

相關(guān)熱詞搜索：蛋白 血清 孕期 糖尿病 差異