摘 要 目的：觀察中藥鴉膽子外敷封包聯(lián)合卡介苗多糖核酸治療多發(fā)性跖疣的臨床療效及安全性。方法：收集2011年10月—2016年10月收治的多發(fā)性跖疣患者80例，分為對照組和觀察組各40例。對照組應(yīng)用卡介苗多糖核酸2 ml（2支），隔日肌內(nèi)注射1次，18支為1個療程，連續(xù)使用3個療程。觀察組應(yīng)用去殼搗碎鴨蛋子仁外敷，3～4 d換藥1次，注意保護(hù)周圍正常皮膚，并聯(lián)合卡介苗多糖核酸2 ml（2支），隔日肌內(nèi)注射1次，18支為1個療程，連續(xù)使用3個療程。于治療后第4、8周和療程結(jié)束后3個月進(jìn)行隨訪。結(jié)果：治療4周時，對照組和觀察組的有效率分別為40%（16/40）和57.5%（22/40），組間差異無統(tǒng)計學(xué)意義（P>0.05）；治療8周時，有效率分別為55%（23/40）和82.5%（33/40），觀察組明顯優(yōu)于對照組（P<0.05）；治療結(jié)束后3個月，兩組均無復(fù)發(fā)病例。治療組發(fā)現(xiàn)不良反應(yīng)1例，觀察組3例，均較輕。結(jié)論：中藥鴉膽子外敷封包聯(lián)合卡介苗多糖核酸治療多發(fā)性跖疣療效滿意。
　　關(guān)鍵詞 多發(fā)性跖疣；中藥鴉膽子；卡介苗多糖核酸；療效
　　中圖分類號：R752.5+1 文獻(xiàn)標(biāo)志碼：A 文章編號：1006-1533（2018）04-0024-03
　　Observation of Brucea javanica with traditional medicine packet combined with BCG polysaccharide nucleic acid in the treatment of multiple plantar warts
　　YANG Liyun
　�。―epartment of Dermatology of Weifang Community Health Service Center of Pudong New District， Shanghai 200122， China）
　　ABSTRACT Objective： To observe the clinical efficacy and safety of Brucea javanica with traditional medicine packet combined with BCG polysaccharide nucleic acid in the treatment of multiple plantar warts. Methods： Eighty patients with multiple plantar warts from Oct. 2011 to Oct. 2016 were collected and randomly divided into a control group and an observation group with 40 cases each. The control group was treated with BCG polysaccharide nucleic acid 2 ml（2 branches）， intramuscular injection 1 time every other day， 18 branches for 1 course， and 3 courses in continuous use. The observation group was treated with external application of shelled and mashed egg kernel， 3-4 d was replaced by this drug and attention should be paid to the protection of normal skin around the skin， and combined with BCG polysaccharide nucleic acid 2 ml（2 branches）， intramuscular injection 1 time every other day， 18 branches for 1 course， and continuous use of 3 courses. Patients were followed up 4， 8 weeks and 3 months after completion of the treatment course. Results： After 4 weeks of treatment， the effective rates of the control group and the observation group were 40%（16/40） and 57.5%（22/40）， and there was no significant difference between the groups（P>0.05）. After 8 weeks of treatment， the effective rates were 55%（23/40） and 82.5%（33/40）， and the observation group was significantly better than the control group（P<0.05）. Three months after the end of treatment， no recurrence was found in all two groups. One case of adverse reactions was found in the treatment group and 3 cases in the observation group， and they were relatively mild. Conclusion： Application of Brucea javanica with traditional medicine packet combined with BCG polysaccharide nucleic acid in the treatment of multiple plantar warts has satisfactory treatment effect.

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