【摘要】 目的：觀察中西醫(yī)結(jié)合治療小兒慢性腹瀉的效果及對血清相關(guān)炎癥細(xì)胞因子變化表達(dá)的影響。方法：選取筆者所在醫(yī)院收治的200例慢性腹瀉患兒為研究對象，隨機(jī)將其分成試驗(yàn)組和對照組各100例。對照組采用常規(guī)的臨床治療方法，試驗(yàn)組采用中西醫(yī)結(jié)合治療，對兩組患兒治療效果及血清相關(guān)炎癥細(xì)胞因子變化[結(jié)腸黏膜核因子-κB（NF-κB）、腫瘤壞死因子-α（TNF-α）、白介素-6（IL-6）和白介素-8（IL-8）]進(jìn)行對比。結(jié)果：治療后，試驗(yàn)組及對照組臨床治療總有效率分別為96.0%和80.0%，試驗(yàn)組臨床治療總有效率明顯優(yōu)于對照組，差異有統(tǒng)計(jì)學(xué)意義（P<0.05）；試驗(yàn)組不良反應(yīng)發(fā)生率4.0%（4例），明顯低于對照組的12.0%（12例），兩組差異有統(tǒng)計(jì)學(xué)意義（P<0.05）。試驗(yàn)組血清NF-κB、TNF-α、IL-6和IL-8分別為（43.8±11.5）ng/L、（67.9±11.5）pg/ml、（122.2±25.6）pg/ml和（24.6±6.5）ng/ml；對照組血清NF-κB、TNF-α、IL-6和IL-8分別為（85.4±12.6）ng/L、（93.7±14.6）pg/ml、（183.2±31.6）pg/ml和（32.3±7.4）ng/ml；試驗(yàn)組臨床治療血清相關(guān)炎癥細(xì)胞因子明顯低于對照組，差異均有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論：中西醫(yī)結(jié)合治療小兒慢性腹瀉對小兒腸黏膜具有修復(fù)和抗炎作用，抑制NF-κB的激活，下調(diào)TNF-α、IL-6和IL-8，效果顯著，值得臨床上推廣應(yīng)用。
　　【關(guān)鍵詞】 小兒慢性腹瀉； 細(xì)胞因子； 中西醫(yī)
　　doi：10.14033/j.cnki.cfmr.2018.5.003 文獻(xiàn)標(biāo)識碼 A 文章編號 1674-6805（2018）05-0005-03
　　【Abstract】 Objective：To observe the effect of traditional Chinese medicine and western medicine in the treatment of chronic diarrhea in children and the expression of serum related inflammatory cytokines.Method：We selected 200 children with chronic diarrhea in our hospital as the research object，who were randomly divided into the experimental group and the control group of 100 cases.The control group used conventional clinical treatment.The experimental group was treated with traditional Chinese medicine and western medicine.The therapeutic effects of the two groups were compared.The changes of serum-associated inflammatorycytokines[Colonic mucosal nuclear factor-κB（NF-κB），tumor necrosis factor-α（TNF-α），interleukin-6（IL-6） and interleukin-8 （IL-8）] in the two groups were compared.Result：After treatment，The total effective rate of clinical treatment in the experimental group and the control group were 96.0% and 80.0% respectively.The total effective rate of clinical treatment in the experimental group was significantly better than that in the control group（P<0.05）.The adverse reaction rate was 4.0%（4 cases） in the experimental group and 12.0%（12 cases） in the control group，the difference was statistically significant（P<0.05）.The levels of serum NF-κB，TNF-α，IL-6 and IL-8 in the experimental group were （43.8±11.5）ng/L，（67.9±11.5）pg/ml，（122.2±25.6）pg/ml and （24.6±6.5）ng/ml.The levels of serum NF-κB， TNF-α，IL-6 and IL-8 in the control group were （85.4±12.6）ng/L，（93.7±14.6）pg/ml，（183.2±31.6）pg/ml and （32.3±7.4）ng/ml.The serum levels of serum-related inflammatory cytokines in the experimental group were significantly lower than those in the control group（P<0.05）.Conclusion：The combination of traditional Chinese and western medicine in the treatment of chronic diarrhea in children with intestinal inflammation and anti-inflammatory are effect，inhibit NF-κB activation，down-regulation of TNF-α，IL-6 and IL-8，the effect is significant，worthy of clinical application.

相關(guān)熱詞搜索：腹瀉 小兒 中西醫(yī)結(jié)合 觀察 效果