[摘要] 目的 通過(guò)對(duì)唐氏篩查血清學(xué)結(jié)果進(jìn)行回顧性分析，探討輔助生殖技術(shù)（Assisted Reproductive Technology，ART）助孕是否增加唐氏綜合征的風(fēng)險(xiǎn)。 方法 使用1235 AutoDELFIA全自動(dòng)時(shí)間分辨熒光免疫分析系統(tǒng)對(duì)2014年12月～2016年5月期間在我院進(jìn)行產(chǎn)前篩查的52 661例孕婦樣本進(jìn)行孕中期血清學(xué)指標(biāo)檢測(cè)，并隨訪其妊娠結(jié)局。按妊娠方式分為ART妊娠組和自然妊娠組，檢測(cè)指標(biāo)為hAFP MOM值、β-hCG MOM值、PAPPA MOM值等。 結(jié)果 早期篩查結(jié)果顯示，ART妊娠組和自然妊娠組孕婦血清β-hCG MOM，PAPPA MOM，唐氏綜合征高風(fēng)險(xiǎn)、中風(fēng)險(xiǎn)和低風(fēng)險(xiǎn)比例比較，差異無(wú)統(tǒng)計(jì)學(xué)意義（P>0.05）。中期篩查結(jié)果顯示，ART妊娠組AFP MOM顯著高于自然妊娠組（P<0.001），但唐氏綜合征高風(fēng)險(xiǎn)、中風(fēng)險(xiǎn)和低風(fēng)險(xiǎn)比例比較，差異無(wú)統(tǒng)計(jì)學(xué)意義（P>0.05）。 結(jié)論 產(chǎn)前篩查在預(yù)防及減少唐氏綜合征發(fā)病率上具有重要的臨床價(jià)值，ART技術(shù)并不增加唐氏綜合征風(fēng)險(xiǎn)。
　　[關(guān)鍵詞] 唐氏綜合征；輔助生殖技術(shù)；產(chǎn)前診斷；出生缺陷
　　[中圖分類號(hào)] R714.5 [文獻(xiàn)標(biāo)識(shí)碼] B [文章編號(hào)] 1673-9701（2018）08-0063-04
　　Analysis on serological results of down"s screening in patients receiving assisted reproduction during pregnancy
　　CHENG Zhaojun ZHOU Wenjing FENG Ying LIAN Jiejing WANG Chong
　　Center for Reproductive Medicine， Hangzhou Hospital of Gynecology and Obstetrics ，Hangzhou Women and Children"s Hospital， Hangzhou 310008， China
　　[Abstract] Objective To carry out the retrospective analysis on the serological results of Down"s screening， and to investigate whether assisted reproductive technology（ART） for pregnancy assistance increases the risk of Down"s syndrome. Methods A total of 52661 pregnant women samples receiving prenatal screening in our hospital from December 2014 to May 2016 using the 1235 AutoDELFIA automatic time-resolved fluorescence immunoassay system were given the tests of serological indices during the second trimester， and their pregnancy outcome was followed up. According to the pregnancy method， the patients were divided into ART pregnancy group and natural pregnancy group. The test indices were hAFP MOM value， β-hCG MOM value， PAPPA MOM value， etc. Results The results of early screening showed that the serum levels of β-hCG MOM， PAPPA MOM of pregnant women and the percentages of high risk， middle risk and low risk of Down"s syndrome between the ART pregnancy group and natural pregnancy group were not significantly different（P>0.05）. The results of interim screening showed that AFP MOM in ART pregnancy group was significantly higher than that in natural pregnancy group（P<0.001）. However， there was no significant difference in the percentages of high risk， middle risk and low risk of Down"s syndrome（P>0.05）. Conclusion Prenatal screening in the prevention and reduction of the incidence rate of Down"s syndrome has an important clinical value， and ART does not increase the risk of Down"s syndrome.
　　[Key words] Down"s syndrome； Assisted reproductive technology （ART）； Prenatal diagnosis； Birth defect

相關(guān)熱詞搜索：血清學(xué) 孕期 生殖 患者 輔助