[摘要]目的 探討梅尼埃病經(jīng)耳前耳后注射地塞米松及慶大霉素的臨床治療效果。方法 選取2015年1月～2017年1月我院收治的90例梅尼埃病患者作為研究對象，按照隨機(jī)數(shù)字表法將其分為對照組與研究組，每組各45例。兩組患者均使用地塞米松及慶大霉素治療，對照組患者給予耳前注射方式，研究組患者給予耳后注射方式。比較兩組患者的聽功能、前庭功能及活動(dòng)能力改善效果。結(jié)果 研究組患者的聽功能改善率（33.33%）、眩暈控制率（77.78%）、活動(dòng)能力改善率（80.00%）明顯高于對照組（13.33%，57.78%，60.00%），差異均有統(tǒng)計(jì)學(xué)意義（P<0.05）。結(jié)論 相較于經(jīng)耳前注射地塞米松及慶大霉素治療梅尼埃病，耳后用藥在改善患者聽功能、前庭功能及活動(dòng)能力上的效果更為明顯。
　　[關(guān)鍵詞]梅尼埃病；地塞米松；慶大霉素；耳前；耳后；聽功能；前庭功能；活動(dòng)能力
　　[中圖分類號] R764.33 [文獻(xiàn)標(biāo)識碼] A [文章編號] 1674-4721（2018）2（b）-0129-03
　　Comparison of clinical effect of preauricular and postauricular injection of Dexamethasone and Gentamicin in the treatment of Meniere"s disease
　　LING Yong-wei
　　Department of Otolaryngology，Head and Neck Surgery，the First People′s Hospital of Nankang District，Jiangxi Province，Ganzhou 341400，China
　　[Abstract]Objective To investigate the clinical effect of preauricular and postauricular injection of Dexamethasone and Gentamicin in the treatment of Meniere′s disease.Methods Altogether 90 patients with Meniere′s disease who were treated in our hospital from January 2015 to January 2017 were selected as subjects and divided into research group and control group according to the random number table method.Patients in both groups were treated with Dexamethasone and Gentamicin，and the control group was treated with preauricular injection，and the group was treated with postauricular injection.The improvement effects in auditory function，vestibular function and movement ability were compared between two groups of patients.Results The hearing function improvement rate （33.33%），the vertigo control rate （77.78%） and the activity ability improvement rate （80.00%） in patients of research group were significantly higher than those of the control group （13.33%，57.78%，13.33%），the differences were statistical significance （P<0.05）.Conclusion Compared with preauricular injection of Dexamethasone and Gentamicin in the treatment of Meniere′s disease，postauricular medication achieves more obvious effects in improving patients′ auditory function，vestibular function and movement ability.
　　[Key words]Meniere′s disease；Dexamethasone；Gentamicin；Preauricular；Postauricular；Hearing function；Vestibular function；Movement activity
　　梅尼埃病為典型的特發(fā)性內(nèi)耳疾病，其病理基礎(chǔ)為膜迷路積水，主要癥狀有聽力障礙、眩暈、耳鳴等，并且反復(fù)發(fā)作。關(guān)于該疾病的發(fā)病機(jī)制當(dāng)前并不明確，其中認(rèn)可度較高的為自身炎癥的變態(tài)反應(yīng)、免疫系統(tǒng)異常等[1]。現(xiàn)代藥理學(xué)證實(shí)，使用糖皮質(zhì)激素類藥物能夠有效緩解多種炎性反應(yīng)，減少感染與水腫，加快淋巴液循環(huán)速度，維持耳蝸淋巴液離子的平衡狀態(tài)，提升耳蝸功能[2]。資料顯示，在治療梅尼埃病時(shí)于中耳或內(nèi)耳局部使用糖皮質(zhì)激素與抗生素，能夠取得較為理想的效果[3]。但是關(guān)于耳前或耳后用藥藥的給治療效果造成的差異仍然是臨床上重點(diǎn)研究的課題之一。本研究選取我院收治的90例梅尼埃病患者作為研究對象，探討梅尼埃病經(jīng)耳前耳后注射地塞米松及慶大霉素的臨床治療效果，現(xiàn)報(bào)道如下。

相關(guān)熱詞搜索：慶大霉素 注射 臨床 效果 治療