[摘要] 目的 分析高危型人乳頭瘤病毒分型檢測對宮頸癌及癌前病變篩查的意義。 方法 本文觀察對象為本院2016年7～12月期間收治的50例患者，所有患者均接受高危型人乳頭瘤病毒分型檢測，對檢測情況、檢測對宮頸癌和癌前病變篩查的意義進(jìn)行比較分析。 結(jié)果 高危型人乳頭瘤病毒感染率為60.00%（30/50），經(jīng)宮頸活檢病理學(xué)檢查之后，子宮頸上皮非典型增生Ⅰ率為33.33%，子宮頸上皮非典型增生Ⅱ率為10.00%，子宮頸上皮非典型增生Ⅲ率為26.67%，宮頸癌率為30.00%，發(fā)現(xiàn)不同宮頸病變的高危型人乳頭瘤病毒感染率亦有差異。 結(jié)論 高危型人乳頭瘤病毒分型檢測在宮頸癌與癌前病變篩查當(dāng)中有重要意義與指導(dǎo)作用存在。
　　[關(guān)鍵詞] 宮頸癌；癌前病變；高危型人乳頭瘤病毒；分型檢測
　　[中圖分類號] R737.33 [文獻(xiàn)標(biāo)識碼] B [文章編號] 1673-9701（2018）08-0119-03
　　Significance of typing detection of high risk human papillomavirus in screening cervical cancer and precancerous lesions.
　　WU Jieru
　　Department of Laboratory，Jiangxi Provincial Maternal and Child Health Hospital，Nanchang 330006，China
　　[Abstract] Objective To analyze the significance of high-risk human papillomavirus（HPV） typing detection in screening cervical cancer and precancerous lesions. Methods 50 patients admitted in our hospital between July to December 2016 were observed in this study. All patients underwent high-risk human papillomavirus genotyping detection. The detection situation and the significance of detection in screening cervical cancer and precancerous lesions were compared and analyzed. Results The probability of high-risk human papillomavirus infection was 60.00%（30/50）. After cervical biopsy pathology， the probability of atypical hyperplasiaⅠof cervical epithelium was 33.33% and the probability of atypical hyperplasia Ⅱ of cervical epithelium was 10.00%. The probability of cervical epithelial atypical hyperplasia Ⅲ was 26.67%， the probability of cervical cancer was 30.00%. It was found that there was difference in high-risk human papillomavirus infection probability between different cervical lesions. Conclusion High-risk human papillomavirus（HPV）typing detection plays an important role in screening cervical cancer and precancerous lesions.
　　[Key words] Cervical cancer；Precancerous lesions；High-risk human papillomavirus；Typing detection 女性出現(xiàn)宮頸癌與癌前病變主要誘因即為宮頸長時(shí)間處于持續(xù)性感染高危型人乳頭瘤病毒狀態(tài)中[1]。高危型人乳頭瘤病毒分型主要包含高危型與低危型兩種，而開展高危型人乳頭瘤病毒分型檢測可以對疾病演變情況進(jìn)行診斷，同時(shí)可以對疾病的預(yù)后進(jìn)行有效的評估[2]。本文為分析高危型人乳頭瘤病毒分型檢測應(yīng)用于宮頸癌及癌前病變篩查當(dāng)中的價(jià)值，特抽選部分患者進(jìn)行對比與分析，現(xiàn)報(bào)道如下。
　　1 資料與方法
　　1.1 一般資料
　　選擇2016年7～12月在本院婦產(chǎn)科接受治療的50例患者進(jìn)行研究，年齡21～60歲，平均（45.56±2.08）歲；懷孕次數(shù)為0～5次，平均（2.19±0.37）次；產(chǎn)次0～3次，平均（2.09±0.08）次。
　　入選標(biāo)準(zhǔn)：有經(jīng)歷性生活者；未曾接受過子宮相關(guān)手術(shù)治療者；未患宮頸癌及癌前病變者；有不同程度白帶異常（出血與增多）、宮頸充血癥狀存在者；有完整臨床病歷資料者；對本次研究知情并且自愿加入者；納入研究前3個(gè)月內(nèi)未服用性激素類藥物治療者；納入研究前1周內(nèi)未接受陰道沖洗、陰道注入藥物及藥物涂抹陰道等治療者。
　　排除標(biāo)準(zhǔn)：未曾經(jīng)歷過性生活者；曾接受過子宮相關(guān)手術(shù)治療者；經(jīng)臨床相關(guān)診斷及檢查措施被確診為癌前病變或者宮頸癌者；同期有加入其他研究項(xiàng)目者；無意愿納入至本次研究者。

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