中圖分類號 R256.23 文獻標(biāo)志碼 A 文章編號 1001-0408（2018）23-3236-05
　　DOI 10.6039/j.issn.1001-0408.2018.23.15
　　摘 要 目的：分析治療失眠膏方的組方規(guī)律，為中醫(yī)治療失眠提供參考。方法：整理《中醫(yī)方劑大辭典》《中醫(yī)膏丹丸散大典·膏劑分典》《中華膏滋方系列叢書》等記載的治療失眠的膏方，并錄入中醫(yī)傳承輔助平臺軟件V2.5中統(tǒng)計藥材用藥頻次；運用Apriori算法及關(guān)聯(lián)規(guī)則對膏方核心組合進行統(tǒng)計分析（支持度為20%，置信度為0.80）；采用熵聚類算法統(tǒng)計2味不同藥材間的關(guān)聯(lián)系數(shù)（相關(guān)系數(shù)為8，懲罰系數(shù)為2）和3、4味藥材核心組合，根據(jù)無監(jiān)督的熵層次聚類法提取新方。結(jié)果：共篩選出125首治療失眠的膏方，包含236種藥材，其中用藥頻次≥20次的有28味，安神藥7味、養(yǎng)血補肝藥5味、健脾祛濕藥3味、補氣藥5味、補血藥4味、活血藥2味、清熱藥2味；得到常用藥材組合28個，其中頻次排前3的藥材組合分別為酸棗仁-遠志、茯苓-酸棗仁、茯苓-遠志，茯苓、酸棗仁、遠志分別具有健脾化濕、養(yǎng)心安神、寧心定志的功效；得到關(guān)聯(lián)規(guī)則12個，3味藥材核心組合56個，4味藥材核心組合16個；提取治療失眠的新方7首。結(jié)論：失眠膏方單味藥功效以安神、養(yǎng)血補肝、補氣活血為主。膏方藥材組合功效以健脾、養(yǎng)心、定志為主。新方組方特點呈現(xiàn)多樣性，以疏肝瀉火、解郁安神、消導(dǎo)和中為主，可為臨床治療失眠提供參考。
　　關(guān)鍵詞 膏方；失眠；Apriori算法；組方規(guī)律；中醫(yī)傳承輔助平臺
　　ABSTRACT OBJECTIVE： To analyze the composition rules of paste formulas for insomnia and to provide reference for TCM in the treatment of insomnia. METHODS： The paste formulas for insomnia were collected from TCM Prescription Dictionary， TCM Plaster Pill Powder Dictionary·Ointment Sub-dictionary and Zhonghua Gao Zi Formula Series. The paste formulas were imported into the software of TCM inheritance support platform V2.5 to count the frequency of drug use. Apriori algorithm and association rules were used to analyze core combination of paste formulas statistically （support degree of 20%， confidence degree of 0.80）. Entropy clustering algorithm was used to calculate the correlation coefficients 2 ingredients of different medicines （correlation coefficient of 8， penalty coefficient of 2） and the core combination of medecine 3 and 4 ingredients. The new formula was extracted by unsupervised entropy hierarchical clustering method. RESULTS： Totally 125 paste formulas including 236 medicinal herbs were screened； the use frequency of 28 ingredients was greater or equal to 20 times， there were 7 ingredients for sedation， 5 ingredients for nourishing the blood and nourishing the liver， 3 ingredients for invigorating the spleen and dispelling dampness， 5 ingredients for eich the qi， 4 ingredients for invigorate the supplement of blood， 2 ingredients for invigorate the circulation of blood， 2 ingredients for clearing heat. There were 28 common couplet medicines； top 3 couplet medicines in the list of frequency were Z. jujube-P. tenuifolia， P. cocos-Z. jujube， P. cocos-P. tenuifolia. P. cocos， Z. jujube and P. tenuifolia had the functions of invigorating the spleen and dampness， nourishing the mind， tranquilizing the mind and settling mind. 12 correlation regularities， 56 core combinations of 3 ingredients and 16 core combinations of 4 ingredients were obtained，and 7 new formulas for insomnia were obtained. CONCLUSIONS： The effect of the single ingredients of paste formulas for insomnia is to calm the mind， nourish the blood and soften the liver， eich the qi and activate blood. The effects of paste formula combinations are mainly strengthening spleen， nourishing heart and settling mind. The characteristics of new formula are diversified， and the law of clearing liver， reducing fire， communicating heart and kidney， eliminating conduction and medium-to-hidden therapy are explored， which can provide reference for clinical treatment of insomnia.

相關(guān)熱詞搜索：傳承 輔助 規(guī)律 中醫(yī) 治療失眠